2023 World Conference on Lung Cancer (Posters)-EP12.01. High-Dose Aumolertinib Combined Intrathecal Chemotherapy for LM from EGFR-Mutated NSCLC with Meningeal Symptoms as the First Symptom

EP12.01. High-Dose Aumolertinib Combined Intrathecal Chemotherapy for LM from EGFR-Mutated NSCLC with Meningeal Symptoms as the First Symptom - PDF(Slides)

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Leptomeningeal metastasis (LM) is a serious complication of non-small cell lung cancer (NSCLC) with limited treatment options and poor prognosis. A case study presented a female patient with a stage IV lung adenocarcinoma and multiple LM lesions. She experienced explosive headaches and vomiting, which were relieved one week later. The patient had an EGFR 21 L858R mutation confirmed by cfDNA in cerebrospinal fluid (CSF). CT scans showed partial remission of lung lesions and complete remission of LM lesions.<br /><br />The study implemented high-dose aumolertinib combined with intrathecal chemotherapy using an Ommaya reservoir. The treatment strategy showed positive results in managing LM with violent meningeal symptoms as the first symptom. It provided a practicable strategy for rescuing therapy for patients with severe meningeal symptoms of leptomeningeal metastases.<br /><br />LM is a complex condition with heterogeneous symptoms and a limited median survival of 3 months. Precision diagnosis and treatment-related decision-making for LM are still areas of uncertainty. This case study contributes to understanding the effectiveness of high-dose aumolertinib combined with intrathecal chemotherapy as a potential treatment option for LM from NSCLC.<br /><br />While this case study highlights a successful treatment approach, it is important to note that this is a single case and further research is needed to validate its efficacy. Nevertheless, it offers insights into potential therapeutic options for managing LM in NSCLC patients and improving their quality of life.

Asset Subtitle

Wei Wang

Meta Tag

Speaker Wei Wang

Topic Metastatic NSCLC: Targeted Therapy - EGFR/HER2

Keywords

Leptomeningeal metastasis

non-small cell lung cancer

NSCLC

complication

poor prognosis

case study

adenocarcinoma

EGFR mutation

intrathecal chemotherapy

therapeutic options