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2023 World Conference on Lung Cancer (Posters)
EP12.01. The Safety and Efficacy of Aumolertinib i ...
EP12.01. The Safety and Efficacy of Aumolertinib in Advanced EGFR-mutant NSCLC Patients Who Were Intolerant to Osimertinib Treatment - PDF(Abstract)
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Pdf Summary
The study evaluated the safety and efficacy of aumolertinib, a treatment for advanced EGFR-mutant non-small cell lung cancer (NSCLC), in patients who were intolerant to osimertinib. It enrolled 9 patients who were receiving aumolertinib between April 2019 and December 2022. Adverse events were graded and the primary endpoint was the 3-month conversion success rate, defined as the proportion of patients who did not experience grade 2 hematologic toxicity or grade 3 other adverse events within 3 months of switching to aumolertinib. Secondary endpoints included progression-free survival, objective response rate, disease control rate, and overall survival.<br /><br />The results showed that the 3-month conversion success rate was 100%, indicating that all patients did not experience grade 2 hematologic toxicity or grade 3 adverse events within 3 months of starting aumolertinib. The objective response rate was 33.3% and the disease control rate was 100%. The progression-free survival and overall survival have not been reached yet. Some adverse events were observed, including grade 3 rash in 4 patients and grade 2 platelet count decrease in 5 patients. However, both platelet count decrease and rash were not observed according to the CTCAE v5.0 grading criteria.<br /><br />Based on these findings, the study concluded that aumolertinib is a safe and effective option for patients with locally advanced or metastatic EGFR-mutant NSCLC who were intolerant to osimertinib treatment. This provides an alternative treatment option for patients who experience adverse events with osimertinib. Overall, the study highlights the potential of aumolertinib in improving outcomes for patients with EGFR-mutant NSCLC.
Asset Subtitle
Qinhong Zheng
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Speaker
Qinhong Zheng
Topic
Metastatic NSCLC: Targeted Therapy - EGFR/HER2
Keywords
aumolertinib
EGFR-mutant non-small cell lung cancer
osimertinib intolerance
safety
efficacy
adverse events
conversion success rate
progression-free survival
objective response rate
disease control rate
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