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2023 World Conference on Lung Cancer (Posters)
EP12.02. Prevalence and Treatment of Advanced NSCL ...
EP12.02. Prevalence and Treatment of Advanced NSCLC patients with REarranged During Transfection [RET]-fusion at a South Korean Centre - PDF(Abstract)
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This study presented at the WCLC 2023 conference in South Korea focused on the prevalence and treatment of advanced non-small cell lung cancer (NSCLC) patients with RET fusions. RET fusions occur in 1-2% of NSCLC patients globally and an estimated 1.9-6% of cases in South Korea. The study analyzed data from the Asan Medical Center (AMC) and found that 4.3% of stage IIIB-IV NSCLC patients tested positive for RET fusions. The most common fusion partners were KIF5B and CCDC6. Systemic Anti-Cancer Therapy (SACT) was the most common first treatment for RET fusion-positive patients, followed by SACT in combination with radiotherapy. The majority of stage IV NSCLC patients received platinum-based chemotherapy doublet as their first-line treatment. Treatment through clinical trials and tyrosine kinase inhibitor (TKI) monotherapy were also common treatment options. The study found that the overall survival of RET fusion-positive NSCLC patients was 71% at 60 months. The authors concluded that the prevalence of RET fusions in NSCLC patients in South Korea is higher than the global average but within the range reported in South Korea. The treatment patterns observed in this study, including the use of selective RET inhibitors and enrollment in clinical trials, suggest that targeted therapies are being utilized for RET fusion-positive NSCLC.
Asset Subtitle
Shinkyo Yoon
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Speaker
Shinkyo Yoon
Topic
Metastatic NSCLC: Targeted Therapy - FUSIONS
Keywords
NSCLC
RET fusions
Asan Medical Center
stage IIIB-IV
KIF5B
CCDC6
Systemic Anti-Cancer Therapy
SACT
clinical trials
targeted therapies
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