2023 World Conference on Lung Cancer (Posters)-EP13.01. Immunohistochemical Classification of Patients with Small Cell Lung Cancer - A Single Center Study

EP13.01. Immunohistochemical Classification of Patients with Small Cell Lung Cancer - A Single Center Study - PDF(Slides)

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This study aimed to examine the molecular subtyping of small cell lung cancer (SCLC) tumors using immunohistochemical (IHC) staining and investigate its correlation with treatment efficacy in Asian patients. The researchers analyzed 72 tumor samples from patients with SCLC using IHC staining to measure the expression of four transcription factors and conventional SCLC markers. The subtypes were defined based on the relative expression levels of the transcription factors.<br /><br />The results showed that ASCL1 was the most prevalent molecular subtype identified using IHC-based subtyping in SCLC tumors, while no tumors demonstrated predominant YAP1 positivity. The study also found that the use of IHC alone for molecular subtyping in SCLC presents challenges due to the frequent co-expression of subtypes and temporal changes following treatment.<br /><br />Overall, this study provides insights into the molecular subtyping of SCLC tumors using IHC staining in Asian patients. However, further research is needed to better understand the correlation between different subtypes and treatment efficacy in SCLC.

Asset Subtitle

Chi-Lu Chiang

Meta Tag

Speaker Chi-Lu Chiang

Topic SCLC & Neuroendocrine Tumors: Biomarkers & Radiomics

Keywords

molecular subtyping

small cell lung cancer

SCLC tumors

immunohistochemical staining

treatment efficacy

Asian patients

transcription factors

conventional SCLC markers

ASCL1

YAP1 positivity