2023 World Conference on Lung Cancer (Posters)-EP13.01. Prognostic Nutritional Index-Based immune Risk System for Prognosis and Immunotherapy Response Prediction in Small Cell Lung Cancer

EP13.01. Prognostic Nutritional Index-Based immune Risk System for Prognosis and Immunotherapy Response Prediction in Small Cell Lung Cancer - PDF(Slides)

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A new study has proposed a prognostic nutritional index-based immune risk system for prognosis and immunotherapy response prediction in small cell lung cancer (SCLC). The objective of the study was to evaluate the systemic immune indicators and their association with tumor-infiltrating lymphocyte intensity, treatment response, and survival. The study found that the prognostic nutritional index (PNI) was a strong independent prognostic factor in SCLC. Additionally, a local immune score system (LISS) was constructed and combined with PNI to establish an immune risk system. The study also found that a high PNI score predicted progression-free survival benefit from PD-L1 blockade. It suggests that patients with PNI-high tumors may have a survival benefit from immune checkpoint inhibitors. The study concludes that this method provides a way to investigate the prognostic value of the overall immune status by combining PNI with local immune biomarkers in SCLC. Moreover, it highlights the potential application of PNI in predicting the efficacy of immunotherapy in SCLC.

Asset Subtitle

Chaoqiang Deng

Meta Tag

Speaker Chaoqiang Deng

Topic SCLC & Neuroendocrine Tumors: Biomarkers & Radiomics

Keywords

prognostic nutritional index

immune risk system

small cell lung cancer

SCLC

systemic immune indicators

tumor-infiltrating lymphocyte intensity

prognostic factor

local immune score system

PD-L1 blockade

immunotherapy