2023 World Conference on Lung Cancer (Posters)-EP13.01. Stratified Control Study Of Neuroendocrine Differentiation and Potential Clinicopathologic Markers

EP13.01. Stratified Control Study Of Neuroendocrine Differentiation and Potential Clinicopathologic Markers - PDF(Abstract)

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A study conducted by researchers at the Chinese Academy of Medical Sciences and Peking Union Medical College aimed to explore potential markers for neuroendocrine (NE) differentiation and subgrouping in small cell lung cancer (SCLC). SCLC is highly heterogeneous, and previous gene-based classifications have not been practical for clinical application. The researchers focused on insulinoma-associated protein 1 (INSM1) as a potential marker for NE subtyping. <br /><br />The study involved 247 surgical specimens, with quantitative detection of NE mRNA genes and INSM1 protein performed on 48 whole slides. The results showed that INSM1 expression had significant consistency with NE gene expression, indicating its potential as a substitute marker for NE subtyping. NE-high and NE(INSM1)-high subtypes were associated with advanced stages of SCLC and poor prognosis. INSM1 expression also showed correlation with traditional NE markers CD56, ChrA, and Syn, particularly in triple negative cases. NE(INSM1)-high patients showed more bronchial invasion and tumor thrombosis. <br /><br />In conclusion, INSM1 has great potential as a marker for NE differentiation and subgrouping in SCLC. It shows correlation with prognosis and some clinicopathological factors, and its discovery as a molecular subtyping marker could improve patient stratification and prognosis. Further research and validation are needed to establish its clinical applicability.<br /><br />Keywords: INSM1, Small Cell Lung Cancer, Neuroendocrine subtype.

Asset Subtitle

LI LIU

Meta Tag

Speaker LI LIU

Topic SCLC & Neuroendocrine Tumors: Biomarkers & Radiomics

Keywords

INSM1

SCLC

NE differentiation

NE subtyping

gene-based classifications

prognosis

NE markers

triple negative cases

bronchial invasion

molecular subtyping marker