2023 World Conference on Lung Cancer (Posters)-EP13.03. Prophylactic Cranial and Consolidation Thoracic Radiation in Extensive Stage Small Cell (ES-SCLC) Lung Cancer in the Chemo-immunotherapy Era

EP13.03. Prophylactic Cranial and Consolidation Thoracic Radiation in Extensive Stage Small Cell (ES-SCLC) Lung Cancer in the Chemo-immunotherapy Era - PDF(Slides)

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This document is a summary of a study titled "Prophylactic Cranial and Consolidation Thoracic Radiation in Extensive Stage Small Cell (ES-SCLC) Lung Cancer in the Chemo-immunotherapy Era". The study was conducted by researchers from the Department of Radiation Oncology, University Hospitals Cleveland Medical Center, Seidman Cancer Center, the Department of Population and Quantitative Health Sciences, Case Western Reserve University, and the Department of Medicine, University Hospitals Cleveland Medical Center, Seidman Cancer Center.<br /><br />The study aimed to evaluate the role of prophylactic cranial irradiation (PCI) and consolidation thoracic radiation (TRT) in patients with extensive stage small cell lung cancer (ES-SCLC) who underwent initial chemotherapy or chemo-immunotherapy. A total of 163 patients were included in the analysis.<br /><br />The results of the study showed that PCI improved both the median overall survival (mOS) and median progression-free survival (mPFS) in patients with ES-SCLC who responded to chemotherapy or chemo-immunotherapy. However, TRT did not improve mPFS. The presence of liver metastasis and older age were found to be adverse factors for overall survival.<br /><br />The study also found that there was no significant difference in survival outcomes between patients who received chemo-immunotherapy and those who received chemotherapy alone.<br /><br />The researchers concluded that future trials are needed to further evaluate the role of PCI and TRT in combination with chemo-immunotherapy in patients with ES-SCLC.<br /><br />Acknowledgements were given to the collaborators involved in data collection and evaluation.<br /><br />Overall, this study provides insights into the use of PCI and TRT in the treatment of ES-SCLC in the chemo-immunotherapy era and highlights the need for further research in this area.

Asset Subtitle

Tithi Biswas

Meta Tag

Speaker Tithi Biswas

Topic SCLC & Neuroendocrine Tumors: First Line Therapy

Keywords

Prophylactic Cranial Irradiation

Consolidation Thoracic Radiation

Extensive Stage Small Cell Lung Cancer

Chemotherapy

Chemo-immunotherapy

Overall Survival

Progression-free Survival

Liver Metastasis

Older Age

Survival Outcomes