2023 World Conference on Lung Cancer (Posters)-EP13.04. The Impact of PCI on the Prognosis of Limited-stage SCLC Patients in the Era of MRI Surveillance

EP13.04. The Impact of PCI on the Prognosis of Limited-stage SCLC Patients in the Era of MRI Surveillance - PDF(Slides)

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The study conducted by Xiao Hu et al. aimed to evaluate the impact of prophylactic cranial irradiation (PCI) on the prognosis of limited-stage small cell lung cancer (SCLC) patients who achieved complete or partial remission after chemo-radiotherapy (CRT), in the era of brain MRI surveillance. The researchers retrospectively analyzed data from 309 patients with limited-stage SCLC who were enrolled in a prospective study between June 2002 and January 2017. Among the patients who achieved complete remission (CR) after CRT, 29 did not receive PCI, while among those who achieved partial remission (PR), 53 did not receive PCI. The median follow-up times for patients in the CR and PR groups were 22.1 and 15.7 months, respectively.<br /><br />The results of the study showed that PCI significantly reduced the incidence of brain metastasis in both the CR and PR groups. However, the overall survival (OS) rates were not significantly different between patients who received PCI and those who did not in the CR group. In the PR group, PCI was associated with improved OS. The researchers concluded that PCI may be omitted in limited-stage SCLC patients who achieved CR after CRT and instead monitored with brain MRI. However, they emphasized that further prospective studies are needed to confirm these findings.<br /><br />In terms of baseline characteristics, there were no significant differences in age, sex, weight loss, AJCC staging, or PET/CT examination between the PCI and non-PCI groups in both the CR and PR populations. However, patients with a Karnofsky Performance Status (KPS) of 90 were more likely to receive PCI in the CR group.<br /><br />In summary, this study suggests that PCI may not improve overall survival in limited-stage SCLC patients who achieve complete remission after chemo-radiotherapy. However, it may still be beneficial in patients who achieve partial remission. Further studies are needed to validate these findings and determine the optimal approach for surveillance in this patient population.

Asset Subtitle

Xiao Hu

Meta Tag

Speaker Xiao Hu

Topic SCLC & Neuroendocrine Tumors: LS-SCLC

Keywords

prophylactic cranial irradiation

limited-stage small cell lung cancer

chemo-radiotherapy

brain MRI surveillance

complete remission

partial remission

brain metastasis

overall survival

baseline characteristics

Karnofsky Performance Status