2023 World Conference on Lung Cancer (Posters)-EP14.02. Identification of Risk Factors for Postoperative Acute Exacerbation of Myasthenia Gravis after Total Thymectomy

EP14.02. Identification of Risk Factors for Postoperative Acute Exacerbation of Myasthenia Gravis after Total Thymectomy - PDF(Abstract)

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This study aimed to identify the risk factors for postoperative acute exacerbation (AE) of myasthenia gravis (MG) after total thymectomy in patients with thymoma. The researchers examined the clinicopathological features of 237 patients with thymoma who underwent surgical resection between 2000 and 2020. The diagnosis of MG was based on physical and electromyographic findings by neurologists. Postoperative AE of MG was defined as new-onset MG within 30 days after the operation or an increase in the quantitative MG score by more than three points within 30 days after the operation.<br /><br />Out of the 237 patients, 54 (22.8%) had been diagnosed with thymoma with preoperative MG. Among these patients, 9 (4.9%) developed postoperative AE of MG, 7 (3.8%) developed respiratory failure, and 2 (1.1%) showed deterioration of bulbar symptoms. The median level of the serum anti-acetylcholine receptor antibody was 19 nmol/l. The researchers found that preoperative bulbar syndrome, high levels of anti-acetylcholine receptor antibody, longer operation time, and increased bleeding were associated with postoperative AE in patients with thymoma and MG.<br /><br />The study concluded that patients with thymoma and MG should be managed with attention to perioperative AE. The identified risk factors, including preoperative bulbar syndrome, operation time, blood loss, and high levels of anti-acetylcholine receptor antibody, should be taken into consideration when treating these patients.<br /><br />In summary, this study identified several risk factors for postoperative AE of MG in patients with thymoma, including preoperative bulbar syndrome, high levels of anti-acetylcholine receptor antibody, longer operation time, and increased bleeding. These findings emphasize the importance of managing patients with thymoma and MG with care and attention to perioperative AE.

Asset Subtitle

Kyohei Masai

Meta Tag

Speaker Kyohei Masai

Topic Thymic Malignancy

Keywords

risk factors

postoperative acute exacerbation

myasthenia gravis

total thymectomy

thymoma

clinicopathological features

surgical resection

diagnosis

respiratory failure

bulbar symptoms