2023 World Conference on Lung Cancer (Posters)-EP14.02. Identification of Risk Factors for Postoperative Acute Exacerbation of Myasthenia Gravis after Total Thymectomy

EP14.02. Identification of Risk Factors for Postoperative Acute Exacerbation of Myasthenia Gravis after Total Thymectomy - PDF(Slides)

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In this study, the researchers aimed to identify risk factors for postoperative acute exacerbation (AE) of myasthenia gravis (MG) after total thymectomy. They retrospectively collected data from 250 patients with thymoma who underwent complete resection between 2000 and 2022. The patients' clinical disabilities and severity of MG symptoms were evaluated using the MGFA clinical classification and QMG score, respectively. The researchers defined postoperative AE as new-onset MG within 30 days after the operation or a rise of more than three points in the QMG score within 30 days after the operation.<br /><br />The results showed that among the 250 patients, 55 had preoperative MG and 11 of them (20%) developed AE of MG postoperatively. The presence of preoperative bulbar syndrome, high levels of anti-AchR antibody, longer anesthesia and surgical times, and increased bleeding were found to be associated with postoperative AE in patients with thymoma and MG. Specifically, 7 cases of AE developed respiratory failure, and 4 cases showed deterioration of bulbar symptoms.<br /><br />The researchers concluded that preoperative bulbar syndrome and high levels of anti-AchR antibody are risk factors for postoperative AE of MG in patients with thymoma and MG. They emphasize the importance of managing these patients with attention to perioperative AE.<br /><br />Overall, this study provides insights into the risk factors for postoperative AE of MG after total thymectomy in patients with thymoma. The findings can help guide clinical management and improve patient outcomes. Further research is needed to validate these findings and explore potential preventive strategies for postoperative AE in this patient population.

Asset Subtitle

Kyohei Masai

Meta Tag

Speaker Kyohei Masai

Topic Thymic Malignancy

Keywords

study

researchers

risk factors

postoperative AE

myasthenia gravis

thymectomy

thymoma

bulbar syndrome

anti-AchR antibody

perioperative AE