2023 World Conference on Lung Cancer (Posters)-EP17.04. Lung Cancer Care in Singapore: A review of the Healthcare Registry, 2013-2020

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Lung cancer is a significant health challenge in Singapore, particularly among the aging population. It is the leading cause of cancer death in men and among the most common cancers in both men and women. In recent years, advancements in targeted therapy and immune checkpoint inhibitors have improved prognosis and quality of life for lung cancer patients. However, there is limited evidence on improved overall survival in Singapore due to novel treatment guidelines. <br /><br />To gain insights into lung cancer care in Singapore, a retrospective cohort study was conducted using data from the Hospital Cancer Registry from 2013 to 2020. The study included 2,192 patients, with most being male (66%) and having a history of smoking (56%). The incidence of lung cancer in Singapore has increased over the study period, from 259 cases in 2013 to 318 cases in 2020. <br /><br />The majority of patients presented with metastatic disease at the time of diagnosis, and this remained stable throughout the study period. Among patients with non-small cell lung cancer (NSCLC), 75% had non-squamous NSCLC. The study found high rates of testing for EGFR mutations, ALK gene rearrangement, and PD-L1 expression in patients with advanced stage NSCLC. <br /><br />The use of targeted therapy as a first-line treatment for stage 4 NSCLC remained constant, while the use of immunotherapy increased from 0% in 2013 to 28% in 2020. 1-year overall survival for stage 4 NSCLC has improved from 47% to 69%. The study also revealed different survival rates for different stages and histological subtypes of NSCLC. <br /><br />In conclusion, the study highlights the high rates of molecular and PD-L1 testing in Singapore and the positive impact of targeted therapy and immunotherapy on overall survival. However, there is a need for early detection of lung cancer to further improve survival rates.

Asset Subtitle

Jia Li Low

Meta Tag

Speaker Jia Li Low

Topic Global Health, Health Services & Health Economics: Real World Data

Keywords

Lung cancer

Singapore

aging population

targeted therapy

immune checkpoint inhibitors

overall survival

retrospective cohort study

metastatic disease

PD-L1 expression

early detection