2023 World Conference on Lung Cancer (Posters)-P1.09. DCBLD2 Impacts Tumor Immune-Vascular Microenvironment of Lung Cancer by Inducing Pro-angiogenic Macrophages

P1.09. DCBLD2 Impacts Tumor Immune-Vascular Microenvironment of Lung Cancer by Inducing Pro-angiogenic Macrophages - PDF(Abstract)

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In this study presented at the WCLC 2023 conference, the authors investigated the role of DCBLD2 in the tumor immune-vascular microenvironment (TME) of lung cancer. They found that DCBLD2, a protein associated with angiogenesis, is highly expressed in tumor tissue and is associated with poor prognosis in lung cancer patients. Through in vivo and in vitro experiments, the authors demonstrated that overexpression of DCBLD2 accelerates tumor growth but also improves tumor control after receiving anti-angiogenic therapy. Mechanistically, DCBLD2 induces angiogenesis and the formation of an immunosuppressive microenvironment characterized by increased vessel distribution, infiltration of tumor-associated macrophages (TAMs), and fewer CD8 T cells. Additionally, the authors identified a subpopulation of TAMs, called ISG15 pro-angiogenic TAMs, that are domesticated by DCBLD2-highly expressed lung cancer cells and play a key role in the development of the immunosuppressive microenvironment. This subpopulation of TAMs is associated with a worse prognosis for lung cancer patients. <br /><br />Overall, the results of this study suggest that DCBLD2 promotes angiogenesis and reshapes the TME by inducing pro-angiogenic macrophages. This finding has implications for the prognosis of lung cancer patients and the efficacy of anti-angiogenic therapy. By understanding the role of DCBLD2 in the TME, future studies may be able to develop targeted therapies to disrupt this pathway and improve outcomes for lung cancer patients.

Asset Subtitle

Bai Xue

Meta Tag

Speaker Bai Xue

Topic Tumor Biology: Translational Biology - IO

Keywords

DCBLD2

tumor immune-vascular microenvironment

lung cancer

angiogenesis

poor prognosis

tumor tissue

anti-angiogenic therapy

tumor growth

immunosuppressive microenvironment

TAMs