2023 World Conference on Lung Cancer (Posters)-P1.12. APC-1, A Novel Aptamer-Cisplatin Conjugate, Exhibits Promising Anti-tumor Effect in Lung Cancer

P1.12. APC-1, A Novel Aptamer-Cisplatin Conjugate, Exhibits Promising Anti-tumor Effect in Lung Cancer - PDF(Abstract)

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A study presented at the WCLC 2023 conference titled "APC-1, A Novel Aptamer-Cisplatin Conjugate, Exhibits Promising Anti-tumor Effect in Lung Cancer" discusses a new treatment approach for lung cancer using an aptamer-cisplatin conjugate called APC-1. Cisplatin, a commonly used chemotherapy drug, has limited effectiveness against leptomeningeal metastasis (LM) and is associated with neurotoxicity. <br /><br />The researchers developed APC-1 by conjugating an aptamer with cisplatin. Aptamers are synthetic DNA or RNA oligonucleotides that can target specific molecules. In this case, the aptamer was designed to target lung cancer cells. <br /><br />The study used mouse models to evaluate the efficacy of APC-1. Results showed that APC-1 had a superior tumor suppressive effect compared to cisplatin when administered at an equivalent dose in the lung cancer LM models. In the subcutaneous xenograft models, APC-1 had an identical tumor suppressive effect to cisplatin. Importantly, mice treated with APC-1 did not experience significant weight loss, unlike those treated with cisplatin. <br /><br />The aptamer sequence of APC-1 was detectable in both the plasma and cerebrospinal fluid, suggesting that APC-1 can cross the blood-brain barrier. This finding indicates the potential of APC-1 in treating lung cancer LM. <br /><br />In conclusion, the study demonstrates that APC-1 has a superior tumor suppressive effect at lower systemic cisplatin concentrations compared to cisplatin alone. The ability of APC-1 to penetrate the blood-brain barrier suggests a potential role in treating lung cancer with leptomeningeal metastasis. This research highlights the development of a novel treatment approach for lung cancer using an aptamer-cisplatin conjugate.

Asset Subtitle

Emily Lin

Meta Tag

Speaker Emily Lin

Topic Tumor Biology: Translational Biology - Translational Therapeutics

Keywords

APC-1

aptamer-cisplatin conjugate

lung cancer

chemotherapy

leptomeningeal metastasis

neurotoxicity

tumor suppressive effect

mouse models

blood-brain barrier

novel treatment approach