2023 World Conference on Lung Cancer (Posters)-P1.12. CD66c Activates EGFR Signalling Pathway and Promotes EMT in Lung Adenocarcinoma

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A study presented at the World Conference on Lung Cancer (WCLC) 2023 suggests that CD66c plays a role in promoting the epithelial-mesenchymal transition (EMT) and activating the EGFR signaling pathway in lung adenocarcinoma (LUAD). The researchers found that CD66c is upregulated in LUAD tumors compared to non-tumor tissue. High expression of CD66c is associated with advanced TNM stage, larger tumor size, and lymphatic metastasis. CD66c overexpression is more common in non-smokers, patients receiving chemotherapy, and female LUAD patients.<br /><br />Further investigation revealed that CD66c directly interacts with the extracellular domain of EGFR, leading to the activation of the EGFR/Akt signaling pathway. In vitro and in vivo experiments showed that CD66c promotes EMT and enhances the metastatic ability of LUAD cell lines. This suggests that CD66c could serve as a potential therapeutic target in LUAD.<br /><br />The study also examined the clinical significance of CD66c in LUAD. mRNA and protein expression of CD66c were analyzed in LUAD cell lines, and its subcellular localization was investigated in patient-derived cell lines. Additionally, mRNA expression of CD66c was examined in 57 LUAD primary tumor and adjacent-normal tissue. Clinicopathological correlation analysis was performed on 56 LUAD patients based on the median expression of CD66c in tumor tissue.<br /><br />The research was supported by the Hong Kong Research Grants Council Area of Excellence Scheme. The authors of the study are affiliated with the Department of Surgery at The Chinese University of Hong Kong.<br /><br />In conclusion, the findings suggest that CD66c interacts with EGFR and LGALS3 to activate the EGFR signaling pathway, leading to EMT transition and increased migration in LUAD cells. This highlights the potential of CD66c as a therapeutic target in the treatment of LUAD.

Asset Subtitle

Yushi Li

Meta Tag

Speaker Yushi Li

Topic Tumor Biology: Translational Biology - Translational Therapeutics

Keywords

CD66c

epithelial-mesenchymal transition

EGFR signaling pathway

lung adenocarcinoma

LUAD

tumor tissue

TNM stage

lymphatic metastasis

therapeutic target

migration