2023 World Conference on Lung Cancer (Posters)-P1.12. Sensitization of Cancer Cells to Tumor Treating Fields (TTFields) via Inhibition of the PI3K/AKT Signaling Pathway

P1.12. Sensitization of Cancer Cells to Tumor Treating Fields (TTFields) via Inhibition of the PI3K/AKT Signaling Pathway - PDF(Abstract)

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This abstract discusses the findings of a study on a novel aptamer-cisplatin conjugate called APC-1 and its potential anti-tumor effect in lung cancer. The researchers aimed to address the limited effectiveness and neurotoxicity associated with cisplatin, a commonly used chemotherapy agent. <br /><br />In the study, the aptamer-cisplatin conjugate was tested in lung cancer mouse models, including models of leptomeningeal metastasis (LM) and subcutaneous xenografts. The tumor suppressive effect was compared to cisplatin alone. The results showed that APC-1 exhibited a superior tumor suppressive effect than cisplatin in both LM and subcutaneous xenograft models. Notably, at an equivalent cisplatin dose, APC-1 showed identical tumor suppressive effect to cisplatin, but without significant weight loss in the treated mice. <br /><br />The researchers also identified the aptamer sequence in both the plasma and the cerebrospinal fluid (CSF), suggesting that APC-1 may be able to penetrate the blood-brain barrier (BBB). This finding suggests that APC-1 has potential for the treatment of lung cancer with leptomeningeal metastasis. <br /><br />In conclusion, APC-1, the aptamer-cisplatin conjugate, demonstrated promising anti-tumor effects in lung cancer models, with reduced toxicity compared to cisplatin alone. The ability of APC-1 to penetrate the BBB opens up possibilities for its use in lung cancer with leptomeningeal metastasis. Further research and clinical studies are needed to investigate the potential of APC-1 as a targeted therapy for lung cancer.

Asset Subtitle

Moshe Giladi

Meta Tag

Speaker Moshe Giladi

Topic Tumor Biology: Translational Biology - Translational Therapeutics

Keywords

aptamer-cisplatin conjugate

APC-1

anti-tumor effect

lung cancer

chemotherapy agent

neurotoxicity

mouse models

leptomeningeal metastasis

subcutaneous xenografts

blood-brain barrier