2023 World Conference on Lung Cancer (Posters)-P1.13. Detection of Lung Cancer in People Without a Smoking History Using Exhaled Breath as an Exogenous Probe

P1.13. Detection of Lung Cancer in People Without a Smoking History Using Exhaled Breath as an Exogenous Probe - PDF(Slides)

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This study aimed to compare metabolic pathways in individuals who have never smoked, with and without lung cancer, using exhaled breath analysis after ingesting peppermint oil. The participants were asked to ingest a 200 mg peppermint oil capsule, and breath samples were collected at various time intervals using the ReCIVA device. The breath samples were analyzed for volatile organic compounds (VOCs) using ToF-GC-MS. The study included 36 participants, 17 with cancer and 19 without cancer. The cancer group had slower elimination rates for VOCs compared to the non-cancer group, and the difference was statistically significant for D-Limonene. Seventeen terpenes were detected in breath, with slower elimination times observed for 11 of them in the cancer group. The results suggest that individuals with lung cancer who have never smoked exhibit slower elimination of peppermint metabolites, indicating a difference in the bio-transformation pathway of inhaled carcinogens. The analysis of VOCs in exhaled breath after peppermint oil administration showed consistent differences between cancer patients and controls in absorption and elimination parameters. This method may be promising for identifying individuals who have never smoked but are at high risk for lung cancer. However, further research is needed to evaluate different metabolic pathways involved in the processing of ingested and inhaled carcinogens in vivo. Overall, this study contributes to the understanding of lung cancer risk factors in non-smokers and the potential use of exhaled breath analysis as a diagnostic tool.

Asset Subtitle

Renelle Myers

Meta Tag

Speaker Renelle Myers

Topic Screening & Early Detection: Biomarkers/Imaging Technology

Keywords

metabolic pathways

exhaled breath analysis

peppermint oil

ReCIVA device

volatile organic compounds

ToF-GC-MS

lung cancer

never smoked

bio-transformation pathway

carcinogens