2023 World Conference on Lung Cancer (Posters)-P1.17. Cost-Effectiveness of LDCT Screening in Never Smokers at High Lung-Cancer Risk

P1.17. Cost-Effectiveness of LDCT Screening in Never Smokers at High Lung-Cancer Risk - PDF(Slides)

Pdf Summary

The study examined the cost-effectiveness of low-dose computed tomography (LDCT) screening in never smokers at high risk for lung cancer. The target population for the study was never smokers aged 50-75 who met the criteria of the Taiwan Lung Cancer Screening in Never-Smoker Trial. The perspective of the study was societal, and the willingness-to-pay threshold was 35,000 (1 GDP per capita) per quality-adjusted life year (QALY). The time horizon for the analysis was lifetime, with an annual discount rate of 3%. The study assumed a 2-year lead time for screening-detected lung cancers and that all excess cancers were over-diagnosed.<br /><br />The study used a decision tree model to evaluate the cost-effectiveness of LDCT screening in never smokers. The base case analysis focused on invasive lung cancer, including minimally invasive adenocarcinoma but excluding adenocarcinoma in situ.<br /><br />The results of the analysis showed that LDCT screening would be a cost-effective strategy for high-risk never smokers with a family history of lung cancer. The tornado diagram highlighted the factors that had the greatest impact on the cost-effectiveness of LDCT screening. The study concluded that further research based on repeated screenings is necessary to confirm the findings.<br /><br />In summary, the study found that LDCT screening is a cost-effective strategy for high-risk never smokers with a family history of lung cancer. The results suggest that implementing LDCT screening in this population could help detect lung cancer at an early stage and improve outcomes. Further research is needed to validate these findings.

Asset Subtitle

Szu-Chun Yang

Meta Tag

Speaker Szu-Chun Yang

Topic Screening & Early Detection: Program Design

Keywords

low-dose computed tomography

LDCT screening

never smokers

lung cancer

high risk

cost-effectiveness

family history

tornado diagram

early stage

research