2023 World Conference on Lung Cancer (Posters)-P1.21. PD-L1 Expression in Surgically Resected Lung Pleomorphic Carcinoma - One-centre Study of 107 Patients

P1.21. PD-L1 Expression in Surgically Resected Lung Pleomorphic Carcinoma - One-centre Study of 107 Patients - PDF(Slides)

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This study focuses on the spread of cancer through air spaces (STAS) in surgically resected lung pleomorphic carcinomas (PC). Pleomorphic carcinoma is a rare type of lung cancer characterized by the presence of sarcoma-like features. The researchers wanted to determine the occurrence of STAS in PC and investigate whether there is a relationship between the expression of epithelial-mesenchymal transition (EMT) markers and STAS.<br /><br />The study analyzed 99 patients diagnosed with lung cancer and found that approximately 39% of them had STAS. The expression of E-cadherin (epithelial marker) was stronger and more frequent in the epithelial component compared to the sarcomatous component. On the other hand, vimentin (mesenchymal marker) was more expressed in the sarcomatous component. However, there was no direct relationship between the frequency of STAS and the expression of individual EMT markers. The study did find that the intermediate group (expressing both E-cadherin and vimentin) had a higher frequency of STAS compared to other groups.<br /><br />The presence of STAS was found to have a negative impact on disease-free survival (DFS) in univariate analysis, but this association was not observed in multivariate analysis. However, patients with STAS tended to have poorer overall survival (OS). The expression of EMT markers and the EMT phenotype did not show an association with OS and DFS in univariate analysis. However, in multivariate analysis, the intermediate EMT phenotype was associated with better DFS compared to the epithelial phenotype.<br /><br />Patients with both STAS and the mesenchymal phenotype had worse OS and DFS compared to those without STAS. However, due to the small size of the study groups, these findings should be interpreted with caution.<br /><br />In conclusion, in pleomorphic lung carcinomas, the co-expression of E-cadherin and vimentin is associated with increased STAS frequency. The mesenchymal immunophenotype may be a negative prognostic factor in patients with STAS.

Asset Subtitle

Renata Langfort

Meta Tag

Speaker Renata Langfort

Topic Pathology & Biomarkers: Biomarkers for Immuno-oncology

Keywords

cancer spread

air spaces

STAS

lung pleomorphic carcinomas

sarcoma-like features

EMT markers

E-cadherin

vimentin

disease-free survival

prognostic factor