2023 World Conference on Lung Cancer (Posters)-P1.21. Quantitative Assessment of OX40L and Its Association with Sensitivity to First-Line Pembrolizumab in Non-small-Cell Lung Cancer

P1.21. Quantitative Assessment of OX40L and Its Association with Sensitivity to First-Line Pembrolizumab in Non-small-Cell Lung Cancer - PDF(Slides)

Back to course

Pdf Summary

A study conducted by Baena et al. aimed to identify protein markers associated with the response to pembrolizumab, a type of immunotherapy, in patients with non-small-cell lung cancer (NSCLC) who express high levels of PD-L1. The researchers collected tumor samples from 144 NSCLC patients and used the GeoMx Digital Spatial Profiling system to assess the expression of 36 proteins in the tumor and immune compartments. They found that OX40L, a marker expressed by tumor cells, was consistently associated with prolonged progression-free survival (PFS) in patients with high PD-L1 expression, regardless of PD-L1 levels. OX40L expression was independent of PD-L1 expression in the tumor compartment. Only about 20% of NSCLCs in the study cohort showed prominent levels of OX40L expression. Patients with high OX40L expression had longer PFS compared to those with low OX40L expression. These findings suggest that OX40L expression by tumor cells could be a potential marker for predicting sensitivity to pembrolizumab in NSCLC patients with high PD-L1 expression. The researchers recommend further exploration of the therapeutic potential of modulating the OX40/OX40L axis in combination with PD-1 axis inhibition for this patient subgroup. This study provides insights into the potential mechanisms and biomarkers associated with response to immunotherapy in NSCLC patients with high PD-L1 expression.

Asset Subtitle

Javier Baena

Meta Tag

Speaker Javier Baena

Topic Pathology & Biomarkers: Biomarkers for Immuno-oncology

Keywords

protein markers

pembrolizumab

immunotherapy

NSCLC

PD-L1

OX40L

progression-free survival

therapeutic potential

biomarkers

response to immunotherapy