2023 World Conference on Lung Cancer (Posters)-P1.22. High Incidence of Ischemic Stroke in Patients with Non-small cell lung cancer and RET fusions

P1.22. High Incidence of Ischemic Stroke in Patients with Non-small cell lung cancer and RET fusions - PDF(Slides)

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A monocentric retrospective study was conducted to investigate the incidence of thromboembolic events (TE) in patients with non-small cell lung cancer (NSCLC) and RET fusions. The study included consecutive patients with advanced NSCLC and RET fusions who were seen between 2010 and 2023. TE was defined as deep vein thrombosis (DVT), pulmonary embolism (PE), or arterial thrombosis occurring during cancer evolution or within 6 months prior to cancer diagnosis. Brain imaging was reviewed by a neurologist.<br /><br />The results of the study showed a high incidence of ischemic stroke in patients with NSCLC and RET fusions, similar to patients with ALK or ROS1 fusions. The prevalence of TE in patients with NSCLC and RET fusions was found to be 48% among the 66 patients included in the study. Among the TE events, 24% were DVT, 29% were PE, 15% were ischemic stroke, and 1.5% were marantic endocarditis. Patients with TE were found to be significantly younger compared to those without TE.<br /><br />The study suggests that regular brain MRI surveillance may be necessary for patients with NSCLC and RET fusions due to the preponderance of ischemic strokes. Prophylactic anticoagulation should be considered for high-risk cases, and recommendations are needed for recurrent events.<br /><br />In conclusion, the study highlights the high prevalence of TE, particularly ischemic stroke, in patients with NSCLC and RET fusions. The findings emphasize the importance of screening and management strategies for thromboembolic events in this patient population.

Asset Subtitle

Mihaela Aldea

Meta Tag

Speaker Mihaela Aldea

Topic Pathology & Biomarkers: Genetic Biomarkers

Keywords

retrospective study

thromboembolic events

NSCLC

RET fusions

ischemic stroke

DVT

young patients

brain MRI surveillance

management strategies