2023 World Conference on Lung Cancer (Posters)-P1.22. Predominant Solid Patterns in Advanced EGFR Mutated Lung Adenocarcinoma Treated with TKI Is Associated with Worse Outcomes

P1.22. Predominant Solid Patterns in Advanced EGFR Mutated Lung Adenocarcinoma Treated with TKI Is Associated with Worse Outcomes - PDF(Abstract)

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This study analyzed the outcomes of patients with advanced EGFR mutated lung adenocarcinoma treated with TKI therapy. The researchers retrospectively analyzed data from 333 patients at a Mexican institution. They found that patients with tumors containing solid patterns had worse outcomes compared to those with non-solid patterns. The median progression-free survival (PFS) was 10 months for patients with solid patterns, compared to 17 months for those with non-solid patterns. Similarly, the median overall survival (OS) was 20.9 months for patients with solid patterns, compared to 29.3 months for those with non-solid patterns. In the univariate analysis, the presence of the EGFR mutation type L858R and tumors with solid patterns were associated with a higher risk of death. This association remained significant in the multivariable analysis. The study concludes that high-grade histological patterns, specifically the solid pattern, are associated with worse outcomes in advanced EGFR mutated non-small cell lung cancer treated with TKI therapy. <br /><br />Keywords: EGFR, solid-patterns, TKI

Asset Subtitle

Oscar Arrieta

Meta Tag

Speaker Oscar Arrieta

Topic Pathology & Biomarkers: Genetic Biomarkers

Keywords

EGFR

solid-patterns

TKI

lung adenocarcinoma

advanced

outcomes

progression-free survival

overall survival

histological patterns

non-small cell lung cancer