2023 World Conference on Lung Cancer (Posters)-P1.24. Association between Whole Blood ACTB methylation and Lung Cancer: A Case- Control Study

P1.24. Association between Whole Blood ACTB methylation and Lung Cancer: A Case- Control Study - PDF(Slides)

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A case-control study was conducted to investigate the association between ACTB methylation in peripheral blood and lung cancer (LC). The study found that there is a significant association between ACTB methylation hypermethylation in blood and early LC, particularly in older individuals and males. This suggests that peripheral blood DNA methylation signatures could potentially be used for the early detection of LC. <br /><br />Lung cancer is the leading cause of cancer-related deaths worldwide. DNA methylation is an important epigenetic modification that plays a role in the initiation and progression of cancer. ACTB, which codes for β-actin, a key protein involved in cell structure, has been found to have a critical role in cancer. <br /><br />The study collected blood samples from individuals with and without LC to assess the association between ACTB methylation in whole blood and LC. The results showed that there is enhanced methylation of ACTB in peripheral blood in individuals with LC. Furthermore, this hypermethylation was more prominent in individuals aged 55 and older and in males. <br /><br />Overall, the findings of this study suggest that ACTB methylation in peripheral blood could serve as a potential biomarker for the early detection of LC, especially in older individuals and males. This highlights the importance of considering epigenetic modifications in the development of strategies for the early diagnosis and treatment of LC.

Asset Subtitle

Rongxi Yang

Meta Tag

Speaker Rongxi Yang

Topic Pathology & Biomarkers: Prognostic Biomarkers

Keywords

case-control study

ACTB methylation

peripheral blood

lung cancer

association

hypermethylation

early detection

DNA methylation

β-actin

epigenetic modification