2023 World Conference on Lung Cancer (Posters)-P1.24. Clinical Implication of Karyopherin a 2, Which Is a Nuclear Export Protein in Lung Adenocarcinoma

P1.24. Clinical Implication of Karyopherin a 2, Which Is a Nuclear Export Protein in Lung Adenocarcinoma - PDF(Abstract)

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The study presented at the WCLC 2023 conference aimed to investigate the clinical significance of Karyopherin a 2 (KPNA2), a nuclear export protein, in lung adenocarcinoma. KPNA2 is known to regulate the nuclear import of macromolecules and contribute to carcinogenesis. The researchers retrospectively analyzed data from patients who had undergone curative surgical resection. Immunohistochemistry staining was performed on tumor samples to measure KPNA2 expression. The results showed that high KPNA2 expression was associated with lymphatic invasion, advanced stage, and current smoking. Additionally, squamous cell carcinoma had higher KPNA2 expression compared to adenocarcinoma. Patients with high KPNA2 expression had shorter survival, higher recurrence rates, and poorer survival outcomes. Knocking down KPNA2 in lung cancer cells suppressed migration and invasion in in vitro experiments. The researchers concluded that KPNA2 protein expression has a poor prognostic association and could potentially serve as a therapeutic target or biomarker in lung adenocarcinoma. Further evaluation using an organoid model is planned.

Asset Subtitle

Seoree Kim

Meta Tag

Speaker Seoree Kim

Topic Pathology & Biomarkers: Prognostic Biomarkers

Keywords

KPNA2

lung adenocarcinoma

carcinogenesis

KPNA2 expression

lymphatic invasion

squamous cell carcinoma

survival outcomes

recurrence rates

therapeutic target

biomarker