2023 World Conference on Lung Cancer (Posters)-P1.24. Clinical Implication of Karyopherin a 2, Which Is a Nuclear Export Protein in Lung Adenocarcinoma

P1.24. Clinical Implication of Karyopherin a 2, Which Is a Nuclear Export Protein in Lung Adenocarcinoma - PDF(Slides)

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The study focused on the clinical implications and characterization of karyopherin a 2 (KPNA2), a nuclear export protein in lung adenocarcinoma. The researchers aimed to investigate the clinical significance and metabolic pathway of stable cancer-associated fibroblast (CAF) and cancer cells for KPNA2. <br /><br />The study was conducted using data from 165 non-small cell lung cancer (NSCLC) patients who underwent curative surgical resection. Immunohistochemistry staining was performed on tumor samples to analyze KPNA2 protein expression. The results showed that high KPNA2 expression was associated with lymphatic invasion, advanced stage, and current smoking. KPNA2 expression was higher in squamous cell carcinoma compared to adenocarcinoma.<br /><br />Patients with high KPNA2 expression had shorter survival and higher recurrence rates compared to other patients. Knocking down KPNA2 suppressed the invasion of cancer cells, while overexpressing KPNA2 promoted cancer invasion. These findings suggest that KPNA2 may serve as a poor prognostic marker and as an oncogenic target molecule.<br /><br />In conclusion, the study highlights the clinical significance of KPNA2 in lung adenocarcinoma. Further evaluation of KPNA2 using an organoid model is underway. These findings contribute to a better understanding of the role of KPNA2 in the development and progression of lung adenocarcinoma and may have implications for future treatment strategies.

Asset Subtitle

Seoree Kim

Meta Tag

Speaker Seoree Kim

Topic Pathology & Biomarkers: Prognostic Biomarkers

Keywords

KPNA2

lung adenocarcinoma

clinical implications

metabolic pathway

cancer-associated fibroblast

NSCLC

protein expression

prognostic marker

cancer invasion

organoid model