2023 World Conference on Lung Cancer (Posters)-P1.24. Discovery of Novel Biomarkers of Small Cell Lung Cancer Using Highly Sensitive Quantitative Proteomic Analysis

P1.24. Discovery of Novel Biomarkers of Small Cell Lung Cancer Using Highly Sensitive Quantitative Proteomic Analysis - PDF(Abstract)

Back to course

Pdf Summary

This study focuses on the discovery of novel biomarkers for small cell lung cancer (SCLC) using highly sensitive quantitative proteomic analysis. The researchers collected bronchoalveolar lavage fluid (BALF) from SCLC patients and performed quantitative mass spectrometry analysis to identify differentially expressed proteins. They identified 460 BALF proteins in SCLC patients with significant individual variation. Through immunohistochemical analysis and bioinformatics, they identified CNDP2 and RNPEP as potential subtype markers for ASCL1 and NEUROD1, respectively. They also found that CNDP2 was positively correlated with responses to certain chemotherapy drugs. <br /><br />The study highlights the emerging potential of BALF as a source of biomarkers for lung cancers. By characterizing the proteomes of BALF samples from SCLC patients, the researchers found several proteins that were elevated in tumor-bearing BALF. Specifically, CNDP2 and RNPEP were identified as potential indicators for ASLC1-high and NEUROD1-high subtypes of SCLC. The positive correlation of CNDP2 with chemo-drug responses suggests that it could be used to make treatment decisions for SCLC patients. <br /><br />Overall, the study emphasizes the importance of proteomics and BALF as tools for identifying biomarkers in lung cancer. The researchers suggest that these putative biomarkers should be further investigated for clinical use in precision medicine.

Asset Subtitle

Seung Hyeun Lee

Meta Tag

Speaker Seung Hyeun Lee

Topic Pathology & Biomarkers: Prognostic Biomarkers

Keywords

small cell lung cancer

biomarkers

quantitative proteomic analysis

bronchoalveolar lavage fluid

mass spectrometry analysis

differentially expressed proteins

CNDP2

RNPEP

ASCL1 subtype marker

NEUROD1 subtype marker