2023 World Conference on Lung Cancer (Posters)-P1.24. Effect of Gut Microbiome on Metastasis of Non-small Cell Lung Cancer

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The study investigates the relationship between the gut microbiome and metastasis of non-small cell lung cancer (NSCLC). The researchers enrolled 103 NSCLC patients and divided them into a metastatic group and a non-metastatic group. Fecal samples were collected from all patients before treatment and metagenomic sequencing was performed to compare the differences in intestinal flora between the two groups. <br /><br />The results showed significant differences in the composition of the intestinal flora between the metastatic and non-metastatic groups. The relative abundance of certain bacteria, such as Ruthenibacterium_lactatiformans and Bacteroides_stercoris, was significantly decreased in the metastatic group, while the relative abundance of other bacteria, such as Subdoligranulum, Ruthenibacterium, Fournierella, Ruminococcus_bromii, Subdoligranulum_sp__60_17, and Eubacterium_sp__OM08_24, was significantly increased in the metastatic group. <br /><br />Subgroup analysis within the metastatic group further revealed differences in the relative abundance of certain bacteria depending on the site of metastasis. Additionally, pathway enrichment analysis indicated that the biosynthesis of antibiotics and biosynthesis of secondary metabolites pathways were significantly different between the metastatic and non-metastatic groups. The bacterial secretion system and sulfur relay system pathways were particularly enriched in the metastatic group.<br /><br />The researchers concluded that patients with NSCLC metastasis have a distinct gut microbiome profile and suggested that these unique gut microbiomes could potentially serve as biomarkers for the diagnosis and prognosis of NSCLC metastasis.<br /><br />In summary, the study highlights the importance of the gut microbiome in NSCLC metastasis and suggests that understanding and manipulating the gut microbiome may have implications for the diagnosis and treatment of NSCLC.

Asset Subtitle

Chen-Guang Liu

Meta Tag

Speaker Chen-Guang Liu

Topic Pathology & Biomarkers: Prognostic Biomarkers

Keywords

gut microbiome

metastasis

non-small cell lung cancer

NSCLC

intestinal flora

fecal samples

metagenomic sequencing

bacteria abundance

site of metastasis

biomarkers