2023 World Conference on Lung Cancer (Posters)-P1.24. Effect of Gut Microbiome on Metastasis of Non-small Cell Lung Cancer

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A study conducted by researchers in China investigated the relationship between the gut microbiome and metastasis of non-small cell lung cancer (NSCLC). The study found that patients with NSCLC metastasis had a unique profile of intestinal flora, suggesting that these gut microbiomes could serve as potential biomarkers for diagnosing and predicting the prognosis of NSCLC metastasis.<br /><br />In the study, 103 newly diagnosed NSCLC patients were enrolled and divided into two groups based on the presence or absence of distant metastasis. Fecal samples were collected from all patients before treatment, and metagenomic sequencing was performed to compare the differences in intestinal flora abundance and functional diversity between the two groups.<br /><br />The analysis revealed significant differences in the composition of intestinal flora between the metastatic and non-metastatic groups. Specifically, certain bacteria species were found to be significantly increased or decreased in abundance in the metastatic group compared to the non-metastatic group. Moreover, the study found that the enrichment of certain bacterial pathways, such as biosynthesis of antibiotics and biosynthesis of secondary metabolites, was significantly different between the two groups.<br /><br />Further subgroup analysis within the metastatic group showed differences in the relative abundance of certain bacteria species depending on the site of metastasis. For example, the relative abundance of Akkermansia_muciniphila and Dialister_invisus was lower in the pleural metastatic subgroup compared to patients with metastasis to other organs.<br /><br />Overall, this study provides insights into the relationship between the gut microbiome and metastasis of NSCLC. The unique gut microbiome profile observed in patients with NSCLC metastasis suggests that it could be used as a potential biomarker for diagnosing and predicting the prognosis of NSCLC metastasis. Further research is needed to better understand the underlying mechanisms and potential therapeutic implications.

Asset Subtitle

Chen-Guang Liu

Meta Tag

Speaker Chen-Guang Liu

Topic Pathology & Biomarkers: Prognostic Biomarkers

Keywords

gut microbiome

metastasis

non-small cell lung cancer

NSCLC

intestinal flora

biomarkers

diagnosis

prognosis

metagenomic sequencing

bacterial pathways