2023 World Conference on Lung Cancer (Posters)-P1.25. Comparing Timeliness of Treatment for Surgery vs Radiation for Early-Stage Lung Cancer

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In this study, the authors compare the timeliness of treatment for surgery versus radiation (SBRT) in early-stage non-small cell lung cancer (NSCLC) patients. Lung cancer is the leading cause of cancer death worldwide, but early detection can significantly improve survival. Surgical resection and SBRT are the standard treatment options for clinical stage I lung cancer.<br /><br />The study included patients enrolled in the Mount Sinai Initiative for Early Lung Cancer Research on Treatment (IELCART) between 2016 and 2021 who underwent surgery or SBRT for clinical stage I lung cancer. The time-to-treatment initiation (TTI) measures were derived from the dates of suspicious imaging, biopsy, and treatment. The authors compared TTI measures between surgical and SBRT patients and examined factors associated with longer TTI.<br /><br />Of the 738 participants, the median TTI was 90.5 days. Overall, SBRT patients experienced significantly longer delays in treatment compared to surgical patients. The median TTI from biopsy to treatment was also longer for SBRT patients. However, the difference in TTI from suspicious scan to biopsy between surgical and SBRT patients was not statistically significant.<br /><br />Univariate analysis showed that overall TTI was longer for patients of Black or African American race, individuals with lower education level, presence of vascular disease, COPD, asthma, diabetes, and liver or kidney disease. The multivariable analysis revealed that SBRT, Black or African American race, and the presence of vascular disease were independently associated with increased TTI.<br /><br />The authors conclude that SBRT patients face longer delays to treatment for clinical stage I lung cancer compared to surgical patients. They suggest that as information regarding harms related to treatment delays become more known, more efficient protocols should be developed to reduce treatment delay.<br /><br />The study highlights the importance of timely treatment initiation in early-stage NSCLC and the need for further research to guide recommendations on reducing treatment delay.

Asset Subtitle

Jeffrey Zhu

Meta Tag

Speaker Jeffrey Zhu

Topic Early-Stage NSCLC: Changing Paradigms & Outcomes

Keywords

timeliness of treatment

surgery

radiation

SBRT

early-stage NSCLC

TTI measures

delays in treatment

Black or African American race

vascular disease

reducing treatment delay