2023 World Conference on Lung Cancer (Posters)-P1.26. A Real World Study of Perioperative Outcomes after Minimally Invasive Segmentectomy versus Lobectomy for Early-Stage Lung Cancer

P1.26. A Real World Study of Perioperative Outcomes after Minimally Invasive Segmentectomy versus Lobectomy for Early-Stage Lung Cancer - PDF(Abstract)

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This presentation discusses the results of a real-world study comparing perioperative outcomes of minimally invasive segmentectomy versus lobectomy for early-stage lung cancer. The study included 3280 patients from seven Chinese and Italian centers, and the outcomes were compared after propensity-score matching (PSM). <br /><br />After PSM, 600 patients were included in each group (segmentectomy and lobectomy). The study found that segmentectomy had lower intraoperative bleeding, shorter duration of chest tube, and shorter hospital stays compared to lobectomy. There were no differences in postoperative complications or cardio-pulmonary complications between the two groups. <br /><br />The study also identified three independent predictive factors for postoperative complications: older age (70 years), heavy smoking (current smoker and smoking amount >20 pack/year), and respiratory comorbidity. These factors were used to define high-risk patients, and no differences in perioperative outcomes or postoperative complications were observed between segmentectomy and lobectomy in the matched high-risk patient group.<br /><br />Furthermore, a subgroup analysis was conducted based on the extent of segmentectomy. Segmentectomy of 1/2 lobe was compared to corresponding lobectomy in high-risk patients, and segmentectomy was associated with significantly less morbidity grade 2, respiratory-related morbidity, and respiratory-related morbidity grade 2 compared to lobectomy.<br /><br />In conclusion, minimally invasive segmentectomy is a safe and feasible procedure for patients with stage IA lung cancer. For high-risk patients, segmentectomy of 1/2 lobe may help reduce perioperative risks compared to lobectomy.

Asset Subtitle

Yang Chen

Meta Tag

Speaker Yang Chen

Topic Early-Stage NSCLC: More Minimally Invasive Approaches

Keywords

minimally invasive segmentectomy

lobectomy

perioperative outcomes

early-stage lung cancer

propensity-score matching

intraoperative bleeding

chest tube duration

hospital stays

postoperative complications

cardio-pulmonary complications