2023 World Conference on Lung Cancer (Posters)-P1.26. Harmonized Maximum Standardized Uptake Value as an Indicator for Sublobar Resection: A Multicenter Retrospective Study

P1.26. Harmonized Maximum Standardized Uptake Value as an Indicator for Sublobar Resection: A Multicenter Retrospective Study - PDF(Abstract)

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This study examined the use of harmonized maximum standardized uptake value (SUVmax) as an indicator for sublobar resection in patients with noninvasive lung cancer. The study included 359 patients with clinical stage I non-small cell lung cancer who underwent preoperative CT and PET/CT scans at four different institutions. The aim was to evaluate the predictive performance of the consolidation-to-tumor (C/T) ratio and SUVmax for identifying pathological noninvasive lung cancer.<br /><br />The results showed that the tumor was classified as pathological noninvasive lung cancer in 221 patients. The five-year overall survival (OS) and recurrence-free survival (RFS) rates for these patients were 95.8% and 89.7% respectively. The predictive performance for pathological noninvasive lung cancer was assessed using the area under the curve (AUC) calculated by receiver operating characteristic (ROC) analysis. The AUC for the C/T ratio was 0.693, while the AUC for the harmonized SUVmax (iSUVmax) was 0.828.<br /><br />When comparing iSUVmax and SUVmax, it was found that the difference in classification between the two was small when using a cut-off value of 1.433. The prognosis after surgery was excellent regardless of whether iSUVmax or SUVmax was used.<br /><br />The study concluded that iSUVmax was a better predictor of pathological noninvasive lung cancer compared to the C/T ratio. Despite the difference in measurement between institutions, the use of SUVmax measured at each institution as an indicator for sublobar resection was deemed acceptable in multicenter settings.<br /><br />In summary, this multicenter retrospective study demonstrated the utility of harmonized SUVmax as an indicator for sublobar resection in patients with noninvasive lung cancer. The results suggest that iSUVmax can accurately predict the presence of pathological noninvasive lung cancer, providing valuable information for treatment decisions.

Asset Subtitle

Masahiro Adachi

Meta Tag

Speaker Masahiro Adachi

Topic Early-Stage NSCLC: More Minimally Invasive Approaches

Keywords

SUVmax

sublobar resection

noninvasive lung cancer

CT scan

PET/CT scan

pathological noninvasive lung cancer

overall survival

recurrence-free survival

iSUVmax

multicenter settings