2023 World Conference on Lung Cancer (Posters)-P1.26. Increased Risk of Death from Other Causes After Lobectomy Compared with Sublober Resection in Lung Cancer Patients

P1.26. Increased Risk of Death from Other Causes After Lobectomy Compared with Sublober Resection in Lung Cancer Patients - PDF(Abstract)

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This study aimed to compare the risk of death from other causes after lobectomy (removal of a section of the lung) with sublobar resection (removal of a smaller part of the lung) in lung cancer patients. The researchers retrospectively reviewed 2,121 patients who had undergone curative resection for lung cancer between 2010 and 2017. They compared patient characteristics and overall survival (OS) between those who had lobectomy and those who had sublobar resection.<br /><br />The results showed that the sublobar resection group had a significantly lower risk of death from other causes compared to the lobectomy group. The sublobar resection group had a higher proportion of women, non-smokers, patients without comorbidities, patients with a history of other cancers, patients with earlier-stage disease, and patients with left-sided or lower lobe disease.<br /><br />The median follow-up period was 73 months, and OS was significantly longer in the sublobar resection group compared to the lobectomy group. In a subset analysis adjusted for background factors, OS in the segmentectomy group tended to be longer than in the lobectomy group, although statistical significance was not reached.<br /><br />Risk factor analysis showed that women, age over 65, no comorbidity, stage I disease, and lower lobe disease were associated with an increased risk of death from lobectomy.<br /><br />The researchers concluded that the risk of death from other causes was higher after lobectomy than after sublobar resection, suggesting that preserving more lung tissue may be beneficial. However, they emphasized the need to consider several background factors and validate the findings with larger datasets.<br /><br />Overall, this study provides insights into the potential advantages of less invasive surgical approaches in early-stage non-small cell lung cancer.

Asset Subtitle

Masayuki Nakao

Meta Tag

Speaker Masayuki Nakao

Topic Early-Stage NSCLC: More Minimally Invasive Approaches

Keywords

lobectomy

sublobar resection

lung cancer

death risk

overall survival

patient characteristics

comorbidities

other cancers

follow-up period

segmentectomy