2023 World Conference on Lung Cancer (Posters)-P1.27. Construction of Postoperative Prediction Model Based on the New IASLC Grading System for Early Stage Lung Adenocarcinoma

P1.27. Construction of Postoperative Prediction Model Based on the New IASLC Grading System for Early Stage Lung Adenocarcinoma - PDF(Slides)

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This study aimed to investigate the associations between the new pathological grading system for invasive lung adenocarcinoma (LADC) proposed by the International Association for the Study of Lung Cancer (IASLC) and clinical characteristics and driver gene status. The researchers collected clinical data and survival status of 670 patients with invasive LADC who underwent complete resection. They analyzed the correlations between clinical features, driver gene status, and the new grading system. Prognostic factors for recurrence-free survival (RFS) and overall survival (OS) were identified using univariate and multivariate Cox regression analysis, and prognostic nomograms and prediction models were constructed.<br /><br />The results showed that high pathological grade was more frequent in patients who were male, older than 60 years, had a smoking history, later stage disease, visceral pleural invasion, lymphovascular invasion, and preoperative CEA 5ng/ml. The new grading system, tumor stage, gender, visceral pleural invasion, and lymphovascular invasion were independent predictors of RFS and OS. EGFR-sensitive mutation was associated with low and intermediate pathological grade, while EGFR classic mutation with TP53 co-mutation, ALK/ROS1/RET fusions, and KRAS mutation were often associated with high pathological grade.<br /><br />Nomograms of recurrence and death were constructed using the above-mentioned factors, which had high predictive accuracy. The new grading system contributed the most to the nomograms of recurrence and death. Additionally, the study found that adjuvant therapy could significantly improve RFS in stage IB LADC patients with high pathological grade.<br /><br />In conclusion, this study highlights the importance of the new IASLC grading system in predicting prognosis for early stage LADC and suggests the potential value of postoperative adjuvant therapy in selected patients. The findings provide valuable insights for clinicians in determining treatment strategies and predicting patient outcomes in this population.

Asset Subtitle

Hong Jiang

Meta Tag

Speaker Hong Jiang

Topic Early-Stage NSCLC: Innovation & New Technology

Keywords

pathological grading system

invasive lung adenocarcinoma

International Association for the Study of Lung Cancer

clinical characteristics

driver gene status

complete resection

recurrence-free survival

overall survival

prognostic factors

nomograms