2023 World Conference on Lung Cancer (Posters)-P1.28. Differential Kinetics of Blood and Immune Subpopulations for Cisplatin vs. Sensitizing Paclitaxel Radiotherapy in Locally Advanced Lung Cancer

P1.28. Differential Kinetics of Blood and Immune Subpopulations for Cisplatin vs. Sensitizing Paclitaxel Radiotherapy in Locally Advanced Lung Cancer - PDF(Slides)

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The study focused on comparing the effects of different chemotherapy regimens on circulating blood cells and immune subpopulations in patients with locally advanced lung cancer. The researchers compared the kinetics of blood counts between patients receiving cisplatin-based chemoradiotherapy (CRT), low-dose paclitaxel-CRT, and chest radiotherapy alone.<br /><br />The results showed that cisplatin-CRT had a more pronounced myelosuppressive effect compared to the other two regimens. It led to a significant reduction in red blood cells, platelets, and neutrophils during and after chest radiotherapy. In contrast, the low-dose paclitaxel-CRT did not result in significant declines in blood counts compared to radiotherapy alone.<br /><br />The study also found that all three treatment groups experienced a rapid and profound decline in circulating lymphocytes, reaching their lowest levels by week 2. Both cisplatin-CRT and paclitaxel-CRT had a negative impact on CD19 cells (B cells) at the end of chest radiotherapy. However, the paclitaxel-CRT group had significantly lower levels of CD19 cells compared to the cisplatin-CRT group at the end of the treatment.<br /><br />Furthermore, the paclitaxel-CRT group showed a marked reduction in CD4 cells (helper T cells) compared to radiotherapy alone and cisplatin-CRT. This reduction in CD4 cells was accompanied by increased levels of CD8 cells (cytotoxic T cells) at the end of treatment, which shifted the balance of T-cell subpopulations.<br /><br />Overall, the study concluded that cisplatin-CRT had significant myelosuppressive effects on all three cellular lineages of peripheral blood. In contrast, low-dose paclitaxel-CRT did not significantly reduce blood counts compared to radiotherapy alone. The different treatment regimens also had differential effects on immune subpopulations, with paclitaxel-CRT leading to a shift in the balance of T-cell subpopulations. The clinical implications of these findings in the context of adjuvant immunotherapy after CRT are still unclear and require further investigation.

Asset Subtitle

Yuhchyau Chen

Meta Tag

Speaker Yuhchyau Chen

Topic Local-Regional NSCLC

Keywords

chemotherapy regimens

circulating blood cells

immune subpopulations

locally advanced lung cancer

cisplatin-based chemoradiotherapy

low-dose paclitaxel-CRT

chest radiotherapy

myelosuppressive effect

T-cell subpopulations

adjuvant immunotherapy