2023 World Conference on Lung Cancer (Posters)-P1.28. Dose-Response Relationship Between Radiotherapy and Loss in Lung Perfusion Determined From DECT and PET/CT in NSCLC

P1.28. Dose-Response Relationship Between Radiotherapy and Loss in Lung Perfusion Determined From DECT and PET/CT in NSCLC - PDF(Abstract)

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A study investigated the correlation between radiotherapy dosage and loss of lung perfusion in non-small cell lung cancer (NSCLC) patients. The study compared the dose-response curve (DRC) determined from positron emission tomography (PET) and dual-energy CT (DECT) scans. PET is commonly used to quantify loss in lung perfusion, but DECT with contrast is a potential alternative. The study analyzed data from NSCLC patients who underwent 68Ga-macroaggregated albumin PET/CT, DECT with contrast, and pulmonary function tests at baseline, 3 months, and 12 months post-treatment. The perfused lung was defined using %SUVmax in PET and %IoMax in DECT. The DRCs were compared by analyzing the difference in slope and the overlap of error bars. The study found that the DRCs determined from PET and DECT were equivalent at 3 and 12 months post-radiotherapy treatment, suggesting that DECT may be interchangeable with PET for assessing lung function in NSCLC patients.

Asset Subtitle

Mathieu Gaudreault

Meta Tag

Speaker Mathieu Gaudreault

Topic Local-Regional NSCLC

Keywords

radiotherapy dosage

lung perfusion

NSCLC patients

dose-response curve

PET

DECT scans

pulmonary function tests

perfusion quantification

lung function assessment

DECT-PET equivalence