2023 World Conference on Lung Cancer (Posters)-P1.28. Treatment Strategies for Locally-advanced NSCLC with Invasive T4 Tumors: A SEER Analysis in the Era of Precision Medicine

P1.28. Treatment Strategies for Locally-advanced NSCLC with Invasive T4 Tumors: A SEER Analysis in the Era of Precision Medicine - PDF(Slides)

Back to course

Pdf Summary

A study conducted using the SEER database analyzed the treatment strategies for locally-advanced non-small cell lung cancer (NSCLC) with invasive T4 tumors in the era of precision medicine. The study aimed to identify the most effective treatment approach for these patients based on survival outcomes.<br /><br />The study included NSCLC patients with central structure invasion under the AJCC 7/8 criteria from 2010 to 2020. Three eras were considered: 2010-2014 for targeted drugs, 2015-2017 for initial approval immune checkpoint inhibitors (ICIs), and 2018-2020 for updated ICIs. The survival benefits were assessed using Kaplan-Meier estimators and Cox proportional hazard models.<br /><br />The results showed that personalized treatment strategies based on precision medicine improved patients' survival. The surgery-based strategy demonstrated superior benefits among patients with major structure invasion. Survival benefits increased over time, with the median overall survival (OS) being 16.0 months for 2010-2014, 19.0 months for 2015-2017, and 21.0 months for 2018-2020. Surgical treatment was found to be superior for invasive T4 NSCLC, significantly prolonging median OS compared to other treatment modalities.<br /><br />The study also found that precision medicine advancements led to improved survival for patients receiving chemoradiation and chemotherapy alone. However, no significant improvement was observed in surgical patients. The robustness of the main outcome was further validated through propensity score matching (PSM), showing a median OS of 41 months for matched surgery-based treatment patients compared to 14 months for matched non-surgery-based treatment patients.<br /><br />In conclusion, the study suggests that surgery-based treatment is the optimal approach for locally-advanced NSCLC with invasive T4 tumors. The advent of precision medicine has brought about improvements in survival outcomes, particularly for patients receiving chemoradiation and chemotherapy alone. These findings contribute to the optimization of personalized treatment strategies for NSCLC patients in the era of precision medicine.

Asset Subtitle

Min Wang

Meta Tag

Speaker Min Wang

Topic Local-Regional NSCLC

Keywords

SEER database

locally-advanced non-small cell lung cancer

invasive T4 tumors

precision medicine

treatment strategies

survival outcomes

targeted drugs

immune checkpoint inhibitors

Kaplan-Meier estimators

Cox proportional hazard models