2023 World Conference on Lung Cancer (Posters)-P2.05. Immune Suppressive Microenvironment in Liver Metastases Contributes to Organ-Specific Response of Immunotherapy

P2.05. Immune Suppressive Microenvironment in Liver Metastases Contributes to Organ-Specific Response of Immunotherapy - PDF(Abstract)

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This research focused on understanding the difference in tumor response to immunotherapy between primary lung lesions (PL) and liver metastases (LM) in non-small cell lung cancer (NSCLC). The study aimed to explore the potential mechanisms by analyzing multi-omics data.<br /><br />A clinical cohort study included NSCLC patients with LM who were receiving immunotherapy. The study found that the disease control rate of LM was lower than that of PL. Some patients showed mixed responses, with LM increasing while PL either increased or responded differently. Genomic analysis revealed similar somatic mutations and tumor mutational burden between PL and LM. However, immune activation-related genes were downregulated in LM, and immune cell infiltration was significantly lower in LM compared to PL.<br /><br />The study highlights that the liver microenvironment in LM may contribute to the inferior response to immunotherapy. The findings suggest that LM may have limited immune activation and infiltration compared to PL, potentially impacting the effectiveness of immunotherapy. These results could help develop more precise immunotherapy strategies for NSCLC patients with LM.<br /><br />The research indicates the importance of considering the tumor microenvironment, particularly in metastatic sites such as the liver, when designing immunotherapy regimens. Understanding the differences in tumor responses and the underlying mechanisms can aid in the development of more effective treatments for patients with NSCLC and liver metastases.

Asset Subtitle

Jia-Yi Deng

Meta Tag

Speaker Jia-Yi Deng

Topic Metastatic NSCLC: Immunotherapy - Biomarker

Keywords

tumor response

immunotherapy

primary lung lesions

liver metastases

non-small cell lung cancer

multi-omics data

disease control rate

genomic analysis

immune activation-related genes

immune cell infiltration