2023 World Conference on Lung Cancer (Posters)-P2.13. Molecular Subtyping of Small Cell Lung Carcinoma: An Attempt at Unravelling Its Biological Heterogeneity

P2.13. Molecular Subtyping of Small Cell Lung Carcinoma: An Attempt at Unravelling Its Biological Heterogeneity - PDF(Slides)

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This study aimed to sub-classify small cell lung carcinoma (SCLC) based on the expression of four transcription regulators - ASCL1, NEUROD1, YAP1, and POU2F3 - to identify different molecular subtypes and analyze their histological and clinical characteristics. The study duration was 8 years and a total of 907 pathologically confirmed SCLC cases were included, with 178 cases analyzed for immunohistochemistry.<br /><br />The study found that SCLC appeared morphologically homogenous but showed clinical and biological heterogeneity. The six identified molecular subtypes were SCLC-A, SCLC-N, dual positive (SCLC AN), SCLC-Y, SCLC-P, and quadruple negative (QN). SCLC-Y/P subtypes had poorer overall survival compared to other subtypes.<br /><br />The study also discussed the therapeutic implications of the different subtypes. RB1-proficient SCLC (6%) exhibited an aggressive and chemo-radio-resistant phenotype, while RB1-wild type SCLC with low NE expression and combined phenotype was associated with poor prognosis. Immunohistochemistry was suggested as a surrogate marker for identifying molecular heterogeneity.<br /><br />The study concluded that subtyping SCLC based on transcription regulators could help in therapeutics and prognostication. Further research is needed to establish this subtyping approach. The study provided insights into the molecular and histological characteristics of SCLC and their correlation with clinical parameters.<br /><br />Overall, this study contributes to the understanding of the biological heterogeneity of SCLC and highlights the potential of molecular subtyping for personalized treatment approaches in the future.

Asset Subtitle

Arkadipta Mukherjee

Meta Tag

Speaker Arkadipta Mukherjee

Topic SCLC & Neuroendocrine Tumors: Biomarkers & Radiomics

Keywords

small cell lung carcinoma

SCLC

transcription regulators

ASCL1

NEUROD1

YAP1

POU2F3

molecular subtypes

histological characteristics

clinical characteristics