2023 World Conference on Lung Cancer (Posters)-P2.13. Spatiotemporal Heterogeneity of Transcription Factor-Based Subtype Assignment in Small Cell Lung Carcinoma

P2.13. Spatiotemporal Heterogeneity of Transcription Factor-Based Subtype Assignment in Small Cell Lung Carcinoma - PDF(Slides)

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This study examined the spatiotemporal heterogeneity of transcription factor-based subtypes in small cell lung carcinoma (SCLC). The researchers analyzed tissue samples from patients with SCLC and performed immunohistochemistry for the transcription factors ASCL1, NeuroD1, and POU2F3. They used an H-score system to evaluate the expression of each transcription factor. The study included samples from different anatomic sites and/or different timepoints.<br /><br />The results showed that transcription factor-based subtyping was discordant among multiple samples in 10% of patients, regardless of the sample location or the time lapse between samples. The study also highlighted potential challenges in subtyping, including technical and biological factors that could limit concordance in immunohistochemistry-based subtyping.<br /><br />The findings of this study underscore the spatiotemporal heterogeneity of SCLC in clinical samples. The researchers suggest that future efforts in the clinical application of SCLC subtyping should account for the biological discordance in transcription factor expression.<br /><br />Overall, this study provides important insights into the heterogeneity of SCLC subtypes and highlights the challenges in accurately subtyping SCLC using transcription factor-based methods. Further research is needed to better understand the biological factors that contribute to this heterogeneity and to develop more reliable and accurate subtyping methods for SCLC.

Asset Subtitle

Mari Mino-Kenudson

Meta Tag

Speaker Mari Mino-Kenudson

Topic SCLC & Neuroendocrine Tumors: Biomarkers & Radiomics

Keywords

transcription factor-based subtypes

small cell lung carcinoma

SCLC

spatiotemporal heterogeneity

tissue samples

immunohistochemistry

ASCL1

NeuroD1

POU2F3

H-score system