2023 World Conference on Lung Cancer (Posters)-P2.17. Characterizing Mechanisms of Treatment Resistance in SCLC

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This abstract presents a study conducted to understand the mechanisms of treatment resistance in small cell lung cancer (SCLC) at a cellular level. The researchers performed single cell RNA sequencing (scRNA-seq) on tumor biopsies from five patients with SCLC, including one treatment-naive patient and four patients at relapse. The scRNA-seq data was analyzed to identify transcriptional differences between sensitive (S) and resistant (R) SCLC cells.<br /><br />The results showed significant transcriptional differences between S and R cells, particularly in pathways such as WNT and those governing non-neuroendocrine differentiation. R cells also had a higher degree of cell differentiation compared to treatment-naive and S cells. This increase in cell differentiation may represent a common underlying theme for some of the mechanisms of treatment resistance in SCLC.<br /><br />The researchers further validated their findings using scRNA-seq data from a different dataset consisting of 30,039 SCLC cells. The results from this dataset also showed a higher degree of cell differentiation in R cells compared to S cells.<br /><br />Overall, this study suggests that the mechanisms of treatment resistance in SCLC are heterogeneous, and an increase in cell differentiation may play a role in these mechanisms. Further studies are needed to better understand this phenomenon and validate these observations.<br /><br />The findings of this study provide valuable insights into the understanding of treatment resistance in SCLC and can potentially contribute to the development of novel therapies to improve patient outcomes.

Asset Subtitle

Siddhartha Devarakonda

Meta Tag

Speaker Siddhartha Devarakonda

Topic SCLC & Neuroendocrine Tumors: Relapse & Salvage Therapy

Keywords

treatment resistance

small cell lung cancer

SCLC

cellular level

single cell RNA sequencing

scRNA-seq

transcriptional differences

WNT pathway

non-neuroendocrine differentiation

cell differentiation