2023 World Conference on Lung Cancer (Posters)-P2.20. Clinical Outcome of Patients with Thymic Carcinoma Treated with Preoperative Induction Therapy Followed by Surgical Resection

P2.20. Clinical Outcome of Patients with Thymic Carcinoma Treated with Preoperative Induction Therapy Followed by Surgical Resection - PDF(Slides)

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This study aimed to evaluate the outcomes of surgical resection after preoperative induction therapy for thymic carcinoma with adjacent organ invasion. A total of 17 patients who underwent surgical resection between 2008 and 2022 were retrospectively reviewed. The majority of patients were male (59%), and the median age was 57. Squamous cell carcinoma was the most common pathological type (94%). The clinical stage was mostly IIIa (80%), followed by IIIb (14%) and IVb (6%).<br /><br />Various treatment patterns were observed, with the majority of patients undergoing chemoradiation therapy as neoadjuvant therapy (64%). Surgical procedures included thymectomy combined with resection of adjacent organs (94%) and exploratory thoracotomy (6%). The most common sites for combined resection were the lung and right brachiocephalic vein (41% each).<br /><br />The postoperative course showed low rates of complications, with Grade III complications in only one patient (6%) and no perioperative deaths. Adjuvant therapy, mainly radiotherapy, was given to 24% of patients. The median overall survival was 67 months, and the 5-year overall survival rate was 85%. The median disease-free survival was 28 months, with a 5-year disease-free survival rate of 36%. Recurrence was observed in 59% of patients, with 24% being local and 36% distant.<br /><br />The study's findings suggest that surgical resection after preoperative induction therapy for thymic carcinoma with adjacent organ invasion can be performed safely. The rate of complete resection (R0) was relatively high (76%), and the overall survival was comparable to previous reports. The study concludes that a multidisciplinary approach, including surgery, may be effective in the treatment of locally advanced thymic carcinoma.

Asset Subtitle

Osamu Noritake

Meta Tag

Speaker Osamu Noritake

Topic Thymic Malignancy

Keywords

surgical resection

preoperative induction therapy

thymic carcinoma

adjacent organ invasion

chemoradiation therapy

thymectomy

complications

overall survival

disease-free survival

multidisciplinary approach