2023 World Conference on Lung Cancer (Posters)-P2.20. Does Radical Thymectomy Influence the Neurological Outcome in Patients Aged over 65 with Thymoma and Myasthenia Gravis?

P2.20. Does Radical Thymectomy Influence the Neurological Outcome in Patients Aged over 65 with Thymoma and Myasthenia Gravis? - PDF(Slides)

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This study aimed to investigate the neurological outcome in patients over the age of 65 with thymoma and myasthenia gravis (MG) who underwent radical thymectomy. The researchers analyzed data from 66 patients who had a thymoma associated with MG and were aged 65 years or older. They assessed the neurological outcome using the MGFA Post-Intervention Status (PIS) and evaluated the effect of surgery in these patients.<br /><br />The results showed that after surgery, 12.1% of patients experienced a complete stable response (CSR) and 81.8% had a partial response (PR). The neurological outcome was found to be associated with the surgical approach, with 86% of patients who had a sternotomy reporting a partial response compared to only 14% of patients who had VATS/RATS (video-assisted thoracoscopic surgery/robotic-assisted thoracoscopic surgery). Additionally, patients with a lower pre-operative Osserman score had a higher probability of achieving a complete neurological response.<br /><br />The study concludes that radical thymectomy performed for oncological reasons in patients over 65 years affected by both MG and thymoma is an effective treatment to improve neurological symptoms. More than 10% of patients experienced a complete stable response, and 70% had a partial response. Lower Osserman scores and sternotomy as the surgical approach were associated with a higher likelihood of achieving a complete neurological response.<br /><br />In summary, this research suggests that radical thymectomy can positively impact the neurological outcome in patients over the age of 65 with thymoma and MG. The findings highlight the importance of considering surgical intervention as a treatment option for these patients to help alleviate neurological symptoms.

Asset Subtitle

Filippo Lococo

Meta Tag

Speaker Filippo Lococo

Topic Thymic Malignancy

Keywords

neurological outcome

patients

thymoma

myasthenia gravis

radical thymectomy

partial response

surgical approach

sternotomy

VATS/RATS

Osserman score