2023 World Conference on Lung Cancer (Posters)-P2.20. Thymomatous Myasthenia Gravis after Total Thymectomy at a Tertiary-Care Surgical Centre: a 20-Year Retrospective Review

P2.20. Thymomatous Myasthenia Gravis after Total Thymectomy at a Tertiary-Care Surgical Centre: a 20-Year Retrospective Review - PDF(Slides)

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This study aimed to analyze the incidence and characteristics of thymomatous myasthenia gravis (MG) after total thymectomy at a tertiary-care surgical center. The research team conducted a retrospective review of thymectomy cases performed between 2001 and 2021, as well as collecting data from the Neurology Department EMR system for MG medical management and follow-up. They used univariate and multivariate regression analysis to analyze the data.<br /><br />The results showed that thymomatous MG was associated with a younger mean age and smaller tumor size compared to non-thymomatous MG. Additionally, thymomatous MG was more likely to be associated with germinal cell hyperplasia and cystic lesions.<br /><br />However, there was no difference in the complete MG remission rate after thymectomy between thymomatous and non-thymomatous MG at six months.<br /><br />The study highlights the importance of thymectomy in the management of non-thymomatous MG, as evidenced by improved clinical outcomes such as lower MG scores, medication requirement, and hospitalization rates for exacerbations.<br /><br />The findings also suggest that further research should focus on understanding the role of T-lymphocyte immune response in the pathophysiology of thymomatous MG.<br /><br />In conclusion, this retrospective review provides valuable insights into the incidence and characteristics of thymomatous MG after total thymectomy. Despite the differences in tumor characteristics, the study highlights the comparable remission rates between thymomatous and non-thymomatous MG after thymectomy. These findings contribute to our understanding of the disease and can guide clinical decision-making in the management of thymomatous MG.

Asset Subtitle

Anna McGuire

Meta Tag

Speaker Anna McGuire

Topic Thymic Malignancy

Keywords

thymomatous myasthenia gravis

total thymectomy

retrospective review

germinal cell hyperplasia

cystic lesions

clinical outcomes

T-lymphocyte immune response

remission rates

tumor characteristics

disease management