2023 World Conference on Lung Cancer (Posters)-P2.21. Inflammatory Biomarkers as Prognostic Factors for Malignant Pleural Mesothelioma

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This abstract presents a study on the potential use of inflammatory biomarkers as prognostic factors for malignant pleural mesothelioma (MPM). MPM is a type of cancer that affects the lining of the lungs and thoracic cavity and has limited prognostic markers available for management decisions. The researchers hypothesized that inflammatory biomarkers available through routine blood work could be used to estimate survival in MPM patients.<br /><br />The study involved 448 consecutive MPM patients who were enrolled in a natural history protocol. Blood samples were collected from 246 patients within seven days of enrollment and tested for seven inflammatory biomarkers. These biomarkers included megakaryocyte-potentiating factor (MPF), cancer antigen 125 (CA125), C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), fibrinogen, platelet count, and soluble mesothelin-related peptide (SMRP).<br /><br />The patients were divided into quartiles based on the biomarker data and compared for overall survival using Kaplan-Meier curves. The analysis showed that patients with higher levels of CA125, NLR, and platelet count had significantly lower overall survival rates. The Cox regression model identified SMRP, CRP, and NLR as the best independent predictors of overall survival.<br /><br />Based on the results, the researchers suggest that overall survival in MPM patients is significantly different when stratified by levels of inflammatory biomarkers, particularly SMRP, CRP, and NLR. Patients with lower levels of these biomarkers tend to have longer survival and fewer complications. It is suggested that a prognostic scoring model based on these biomarkers could help clinicians make decisions regarding management options and treatment aggression.<br /><br />Further analysis of SMRP, CRP, and blood count differentials in larger cohorts of MPM patients is recommended.

Asset Subtitle

Keval Yerigeri

Meta Tag

Speaker Keval Yerigeri

Topic Mesothelioma, Thymoma & Other Thoracic Tumors: Translational

Keywords

inflammatory biomarkers

prognostic factors

malignant pleural mesothelioma

cancer

blood work

survival estimation

platelet count

soluble mesothelin-related peptide

overall survival rates

prognostic scoring model