2023 World Conference on Lung Cancer (Posters)-P2.21. Novel microRNAs are Associated with Presence of Pleural Mesothelioma and Response to Chemotherapy

P2.21. Novel microRNAs are Associated with Presence of Pleural Mesothelioma and Response to Chemotherapy - PDF(Abstract)

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This abstract discusses a study that examines the role of novel microRNAs in the presence of pleural mesothelioma (PM) and its response to chemotherapy. The study builds upon previous research that has shown dysregulation of microRNA expression in PM. The researchers used archived tissue samples from PM, non-PM, and lung cancer patients to measure the expression of novel microRNAs using PCR primers. The results showed significantly elevated expression of certain microRNAs in PM compared to both non-PM and lung cancer. Additionally, expression differences were also observed between PM and benign tissue, with the highest difference found for one specific microRNA. The expression of these microRNAs was highest in biphasic PM cases. Furthermore, the study found that microRNA expression was associated with chemotherapy response, with higher expression in patients with progressive disease. These findings suggest a potential diagnostic value of these novel microRNAs in PM and their potential role in chemotherapy response. The researchers plan to further investigate these microRNAs using a different PCR approach and additional microRNA candidates. Overall, this study provides insights into potential biomarkers for PM and their implications in chemotherapy response, which may contribute to improved diagnosis and treatment of this disease.

Asset Subtitle

Michaela Kirschner

Meta Tag

Speaker Michaela Kirschner

Topic Mesothelioma, Thymoma & Other Thoracic Tumors: Translational

Keywords

novel microRNAs

pleural mesothelioma

chemotherapy response

microRNA expression

archived tissue samples

lung cancer patients

benign tissue

biphasic PM cases

diagnostic value

biomarkers