2023 World Conference on Lung Cancer (Posters)-P2.21. Single-Cell Dissection Reveals Mesothelial Heterogeneity and Dysfunctional Immunity in Malignant Pleural Mesothelioma

P2.21. Single-Cell Dissection Reveals Mesothelial Heterogeneity and Dysfunctional Immunity in Malignant Pleural Mesothelioma - PDF(Slides)

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Researchers from China and Switzerland conducted a study to investigate the heterogeneity of mesothelial cells within the human pleural micro-ecosystem and their role in malignant pleural mesothelioma (MPM). The study aimed to provide deeper insights into the pathogenesis of MPM and identify potential therapeutic targets.<br /><br />The researchers used single-cell RNA sequencing (scRNA-seq) to analyze the molecular signatures and differentiated states of mesothelial cells in the normal parietal pleura. They found that there is heterogeneity among mesothelial cells with different molecular signatures and differentiated states.<br /><br />One subset of proliferating mesothelial cells exhibited a primitive cell state, suggesting their potential involvement in the pathogenesis of MPM. The researchers identified CKS2 as a potential novel therapeutic target for treating MPM, as it plays a non-canonical role in the pathogenesis of the disease.<br /><br />Additionally, the researchers found that CD163 macrophages are predominantly distributed around tumor islets in MPM and closely communicate with CD8 T cells, promoting their terminal exhaustion. CD163 macrophages were identified as a critical tissue-resident immune cell population in MPM and are involved in regulating the CD8 T cell response.<br /><br />Overall, this study reveals the heterogeneity of mesothelial cells within the pleural micro-ecosystem and provides insights into the dysfunctional immunity observed in MPM. The findings suggest potential therapeutic targets, such as CKS2, for the treatment of MPM. Understanding the cellular identities and states within the pleura may further improve our understanding of the pathogenesis of MPM and inform novel therapeutic strategies.

Asset Subtitle

Duo Xu

Meta Tag

Speaker Duo Xu

Topic Mesothelioma, Thymoma & Other Thoracic Tumors: Translational

Keywords

mesothelial cells

human pleural micro-ecosystem

malignant pleural mesothelioma

pathogenesis

therapeutic targets

single-cell RNA sequencing

molecular signatures

differentiated states

CKS2

CD163 macrophages