2023 World Conference on Lung Cancer (Posters)-P2.21. The Significance of BAP1 and MTAP/CDKN2A Expression in Well-Differentiated Papillary Mesothelial TUmour: A Series of 21 Cases

P2.21. The Significance of BAP1 and MTAP/CDKN2A Expression in Well-Differentiated Papillary Mesothelial TUmour: A Series of 21 Cases - PDF(Slides)

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In a study of 21 cases of well-differentiated papillary mesothelial tumors (WDPMT), researchers examined the expression of BAP1 and MTAP/CDKN2A to assess their significance in diagnosing malignancy in WDPMT and their relation to mesothelioma in situ (MIS). WDPMT is a common tumor in women with a favorable prognosis, but its association with asbestos is unknown. <br /><br />The study found that loss of BAP1 was associated with progression to mesothelioma. Four out of the 21 patients in the study developed mesothelioma, and all of them showed loss of BAP1 expression. Additionally, five out of eight patients with multifocal WDPMT demonstrated loss of BAP1. On the other hand, all three patients with loss of MTAP/CDKN2A expression did not show progression to mesothelioma. <br /><br />The distinction between WDPMT and papillary MIS requires evaluating BAP1 and MTAP/CDKN2A deletion. The study recommends assessing the expression of these markers to accurately diagnose these lesions. <br /><br />The clinical features of the 21 WDPMT patients were also analyzed. Most of the patients were female and over the age of 50. Some presented with symptoms such as abdominal pain, pleural effusion, or ascites, while others were detected incidentally. The history of asbestos exposure varied among the patients, with some having a documented exposure, some without exposure, and information not available for others. <br /><br />This study provides valuable insights into the significance of BAP1 and MTAP/CDKN2A expression in WDPMT and its relation to mesothelioma. The findings highlight the importance of molecular assessment in accurately diagnosing and predicting the progression of these tumors. Further research is needed to better understand the association between WDPMT, asbestos exposure, and mesothelioma. <br /><br />(Photo: Figure 1A shows the typical appearance of WDPMT on H&E staining, while Figure 1B shows the loss of BAP1 labeling. Figure 2 summarizes the approach to diagnosing WDPMT.)

Asset Subtitle

Sarita Prabhakaran

Meta Tag

Speaker Sarita Prabhakaran

Topic Mesothelioma, Thymoma & Other Thoracic Tumors: Translational

Keywords

well-differentiated papillary mesothelial tumors

WDPMT

BAP1 expression

MTAP/CDKN2A expression

malignancy diagnosis

mesothelioma in situ

asbestos association

clinical features

molecular assessment

asbestos exposure