2023 World Conference on Lung Cancer (Posters)-P2.22. Is the Modified Frailty Index (mFI) a Reliable Predictor of Complications after Transthoracic Esophagectomy?

P2.22. Is the Modified Frailty Index (mFI) a Reliable Predictor of Complications after Transthoracic Esophagectomy? - PDF(Slides)

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The study aimed to determine whether the modified Frailty Index (mFI) is a reliable predictor of complications after transthoracic esophagectomy. Frailty is a state of increased vulnerability to adverse outcomes, often associated with old age, decreased physiological reserves, and the presence of co-morbid conditions. The mFI has previously been validated as a useful tool for predicting post-operative morbidity and mortality.<br /><br />The study conducted a retrospective analysis of a prospectively maintained database. Data collected included patient demographics, stage, co-morbid conditions (including the 11 variables of the mFI), operative details, and post-operative course.<br /><br />Statistical analysis was performed using univariate and multivariate logistic regression to identify factors associated with post-operative complications. The mFI cutoff considered in the study was 0.18. The results showed a trend of increased complications with higher mFI scores, but this was not statistically significant. There was no significant association between mFI and anastomotic leaks or prolonged hospital stay. On multivariate analysis, mFI did not prove to be a significant predictor of post-operative complications or prolonged ICU and hospital stay.<br /><br />The study concluded that while there was a trend of increased complications with a higher mFI score, this was not statistically significant. The results can be partly explained by the younger mean age and fewer patients with cardiac or cerebrovascular co-morbidities undergoing surgery. The mFI as a single frailty index may not be generalizable to various populations, as it does not consider other predictive factors such as pulmonary function, sarcopenia, and nutritional status.<br /><br />In summary, the study found that the mFI was not a reliable predictor of complications after transthoracic esophagectomy. Future research should consider incorporating additional predictive factors to improve the accuracy of risk assessment in this patient population.

Asset Subtitle

Sabita Jiwnani

Meta Tag

Speaker Sabita Jiwnani

Topic Other Thoracic Malignancy

Keywords

modified Frailty Index

complications

transthoracic esophagectomy

frailty

adverse outcomes

old age

physiological reserves

co-morbid conditions

post-operative morbidity

post-operative mortality