2023 World Conference on Lung Cancer (Posters)-P2.31. Real-World Survival Outcomes in NSCLC in Adults Ages 50 and Younger at a Large Academic Institution

P2.31. Real-World Survival Outcomes in NSCLC in Adults Ages 50 and Younger at a Large Academic Institution - PDF(Slides)

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A study conducted at the University of Southern California examined the survival outcomes of young adults with non-small cell lung cancer (NSCLC). The study included 58 NSCLC patients treated from 2015 to 2022 and analyzed their clinical characteristics. The results showed that the majority of the patients were female, of Hispanic ethnicity, and never smokers. Most patients had adenocarcinoma histology and were diagnosed with Stage IV cancer. The study also found that targetable mutations were present in a significant portion of Stage IV patients, with variations in prevalence among different racial/ethnic groups.<br /><br />The document also discusses the results of a study on stage IV NSCLC patients with targetable mutations. The study found that liquid biopsy identified targetable mutations in 13.51% of patients. The median overall survival for metastatic patients was around 50 months. Hispanics had worse survival outcomes compared to Asians and Non-Hispanic Whites. Patients with targetable mutations who were exposed to tyrosine kinase inhibitors (TKIs) had significantly better survival compared to those without targetable mutations. When considering various factors, Hispanic ethnicity was identified as a significant risk factor for survival, but this risk was reduced with TKI treatment. Overall, the study concluded that young NSCLC patients with targetable mutations treated with TKIs had longer survival, and liquid biopsy can increase the chances of identifying these mutations. Additionally, there was a higher mortality risk among Hispanic patients, but this risk was mitigated when treated with TKIs.

Asset Subtitle

Robert Hsu

Meta Tag

Speaker Robert Hsu

Topic Global Health, Health Services & Health Economics: Real World Data

Keywords

University of Southern California

non-small cell lung cancer

NSCLC

survival outcomes

young adults

targetable mutations

liquid biopsy

tyrosine kinase inhibitors

Hispanic ethnicity

overall survival