2024 Asia Conference on Lung Cancer (ACLC) - Poster & ePosters-EP01.06

EP01.06 - Gloriamaris Loy-Caraos

Pdf Summary

The study conducted a meta-analysis to examine the relative risks (RR) of Grade 2 Radiation Pneumonitis (RP) in patients with non-small cell lung cancer (NSCLC) who received stereotactic body radiotherapy (SBRT). RP is known to be an unpredictable side effect of radiotherapy among lung cancer patients. While dose volume histogram (DVH) metrics have previously been used as predictors for RP risk in chemoradiotherapy, their effectiveness in modern SBRT regimens had not been thoroughly investigated. <br /><br />The researchers aimed to determine the relative risks of Grade 2 RP in patients whose radiation exposure exceeded certain DVH cut-off metrics, including Mean Lung Dose (MLD) and total lung volumes receiving 5, 10, and 20 Gy (V5/V10/V20).<br /><br />Using a meta-analysis approach, the study applied a random effects model to assess pooled relative risks. The results indicated increased incidences of RP in patients exposed above the cut-off levels, with pooled incidences of 20% for MLD, 27% for V5, 24% for V10, and 24% for V20. This suggests that exceeding these cut-off values leads to higher relative risks of developing Grade 2 RP.<br /><br />Additionally, the study identified that shorter study durations and observed maximum latency periods significantly influenced these differences in relative risk among various studies.<br /><br />In summary, this research highlights the correlation between exceeding DVH cut-off levels and increased relative risk of RP in SBRT-treated NSCLC patients, suggesting a need for careful consideration of these metrics in treatment planning to mitigate this side effect.

Keywords

meta-analysis

relative risks

Grade 2 Radiation Pneumonitis

non-small cell lung cancer

stereotactic body radiotherapy

dose volume histogram

Mean Lung Dose

V5/V10/V20

treatment planning

side effect mitigation