2024 Asia Conference on Lung Cancer (ACLC) - Poster & ePosters-EP02.01

EP02.01 - Yuquan Bai

Pdf Summary

The study presented at the 2024 Asia Conference on Lung Cancer explores the mechanism of lymph node metastasis (LNM) in patients with T1 stage lung adenocarcinoma (LUAD), a condition where 20% to 30% of patients develop postoperative LNM, affecting survival rates. The researchers used single-cell sequencing data and cell network analysis methods to investigate the role of ITGB1 tumor-associated fibroblasts (CAFs) in this process. <br /><br />The findings revealed that ITGB1 CAFs interact with neutrophils, influencing their infiltration into the tumor site through the secretion of the cytokine IL-8. This interaction promotes the release of neutrophil extracellular traps (NETs), which capture LUAD cells, subsequently promoting their spread to lymph nodes. Multiple analytical techniques, such as immunofluorescence detection and scanning electron microscopy, confirmed these results, demonstrating that ITGB1 CAFs stimulate neutrophil activity and NET formation.<br /><br />The conclusions highlight the potential of ITGB1 CAFs as biomarkers for predicting LNM in T1 stage LUAD patients, offering opportunities for early intervention and improved patient prognosis. The research underlines the significance of targeting the IL-8 mediated pathway in LUAD treatment strategies, aiming to disrupt the process of LNM and thereby enhance survival rates.<br /><br />The study emphasizes the clinical importance of identifying T1 stage LUAD patients susceptible to LNM for timely therapeutic interventions. Corresponding author Dr. Jinbo Zhao, a prominent figure in the field, has an extensive background in thoracic surgery and oncology research, as reflected in numerous scientific publications and patents.

Keywords

lung adenocarcinoma

lymph node metastasis

T1 stage

ITGB1 CAFs

neutrophil extracellular traps

IL-8 cytokine

single-cell sequencing

biomarkers

thoracic surgery

oncology research